Clinical Study Results Show Benefit of FH PRO for Infertile Men
Study Title: Is there a role for oral antioxidants in the treatment of infertile men with high sperm DNA fragmentation?
Authors: Mohamed Arafa, Ahmad Majzoub, Ashok Agarwal, Sami Alsaid, Haitham Elbardisi.
In a prospective clinical trial conducted at the Hamad Medical Center in Doha, Qatar, 101 infertile men with abnormal semen analysis were treated with an antioxidant-based fertility supplement (FH PRO for Men, Fairhaven Health, Bellingham, WA) for 3 months (3 tablets twice daily). Semen samples were analyzed before and after treatment according to WHO 5th edition. Oxidation Reduction Potential (ORP) – a marker of oxidative stress – was measured using the MiOXSYS analyzer, while sperm DNA fragmentation was measured using the Halosperm kit (cut-ff: less than or equal to 30%)
All patients (primary fertility: n-71; secondary infertility: n=30; mean duration: 5.9 +/- 4.2 years; mean age: 35.7 +/- 6.6 years) completed the trial. Compared with the pre-treatment results, there was significant increase in sperm count (from 23.1 +/- 2.6 to 30.8+/-2.8, p<0.001), progressive motility (from 4.1 +/- 0.7 to 9.1 +/-1.1, p<0.001) and normal morphology (from 2.85+/- 0.3 to 4.62+/- 0.3, p<0.001). ORP decreased significantly from 12.2+/- 2.2 to 6.8 +/- 1.6 mv/106/mL (p <0.014). SDF test was done in 72 patients of which 41 had elevated SDF before treatment while 31 were normal. In all patients, SDF significantly decreased from 36.3 +/- 2.3% to 29.04 +/- 1.9%. Specifically, SDF decreased significantly in 35 out of 41 patients with high initial value (from 51.7 +/- 2.2 to 33 +/-2.1, p<0.001). Further SDF became normal in 17 out of 41 patients (41.5%) with high SDF, while 18 out of 41 patients (43.9%) showed significant reduction, but were still high.
Three months treatment with an antioxidant-based fertility supplement (FH PRO for Men) resulted in significant reduction in sperm DNA fragmentation and seminal oxidative stress, and significant improvement in sperm count, progressive motility and morphology.
These results were presented at the at the Foundation for Reproductive Medicine (FRM) annual conference in New York in November 2018.
Supporting Research on Antioxidants
“Antioxidants play an important role in protecting semen from ROS and can improve basic sperm parameters in case of idiopathic oligoasthenoteratozoospermia.” Imamovic Kumalic S and Pinter B. Review of clinical trials on effects of oral antioxidants on basic semen and other parameters in idiopathic oligoasthenoteratozoospermia. Biomed Res Int 2014; 2014:426951.
“The exogenous administration of CoQ10 increases both ubiquinone and ubiquinol levels in semen and can be effective in improving sperm kinetic features in patients affected by idiopathic asthenooospermia.” Balercia G, et al. Coenzyme Q10 and male infertility. J Endocrinol Invest 2009 Jul;32(7):626-32.
“Our results suggest that antioxidant treatment improves sperm quality not only in terms of key seminal parameters and basal DNA damage, but also helps to maintain DNA integrity. Prior administration of antioxidants could therefore promote better outcomes following assisted reproductive techniques.” Abad C, et al. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. Andrologia 2013 Jun:45(3):211-6.
“Treatment of asthenospermic patients with zinc supplementation leads to restored peroxynitrite levels, arginase activity and NO synthase activity to normal values and gives a statistically significant improvement of semen parameters compared with controls.” Hadwan MH, Almashedy LA, Alsalman AR. Study of the effects of oral zinc supplementation on peroxynitrite levels, arginase activity and NO synthase activity in seminal plasma of Iraqi asthenospermic patients. Reprod Biol Endocrinol 2014 Jan 3:12:1
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