Clinical Study Results
Abstract – Role of Antioxidants in Treatment of Infertile Men, FRM
Objective: Sperm DNA fragmentation (SDF) is an important function test showing inverse relation with spontaneous and assisted reproduction. Medical treatments to improve SDF with antioxidants have given controversial results. The objective of this study was to examine the effect of an antioxidant regimen on seminal oxidative stress (OS) and SDF.
Conclusions: Three months treatment with oral antioxidant supplement (FH PRO) resulted in significant improvement in sperm chromatin integrity as measured by SDF as well as a significant decrease in seminal oxidative stress. Improvement in ORP and SDF resulted in significant improvement in sperm count, progressive motility and normal morphology.
Abstract – Effect of Antioxidant Supplementation on the Sperm Proteome, ESHRE
Objective: To determine what changes are observed in the sperm proteome after antioxidant therapy in idiopathic infertile men.
Conclusions: The protein profile of spermatozoa before and after antioxidant treatment are different. There is an upregulation of proteins that are beneficial to spermatozoa after antioxidant treatment. Specifically, of 379 key differentially expressed proteins (DEPs) known to be associated with normal sperm function, supplementation with the antioxidant FH PRO resulted in an overexpression in 274 of those DEPs.
Abstract – Reversal of Oxidative Stress by Antioxidant Therapy, ESHRE
Objective: To determine if supplementation with oral antioxidants can reverse a seminal oxidative stress (OS) state.
Conclusions: Antioxidants can be used to treat seminal OS with subsequent significant improvements in conventional semen parameters and sperm DNA fragmentation (SDF) levels. These improvements are expected to have a favorable effect on the male’s fertility potential.